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Computational modelling of mechanical tests of animal cell
Orlová, Lucie ; Fuis, Vladimír (oponent) ; Burša, Jiří (vedoucí práce)
The presented Master's thesis deals with the structural arrangement of living animal cells and their mechanical behavior under loading. The generalized aim is to describe mechanical responses of cells under either physiological or pathological conditions. A highly interdisciplinary approach interconnecting the computational methods of solid mechanics (finite element method in particular) with medical research is an inseparable part of the problem solution. A crucial step in proposing a computational model for approximation of a living cell behavior under loading conditions is to establish mechanically significant components to be incorporated into the calculation and to identify their material parameters. A presented computational model incorporates continuum entities such as the nucleus, membrane, and cytoplasm interconnected with a discrete mitochondrial network. This results in a novel hybrid model which is validated through comparison with experimental data and serves as a means to estimate the mitochondrial impact on overall cell stiffness.
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Computational modelling of mechanical tests of animal cell
Orlová, Lucie ; Fuis, Vladimír (oponent) ; Burša, Jiří (vedoucí práce)
The presented Master's thesis deals with the structural arrangement of living animal cells and their mechanical behavior under loading. The generalized aim is to describe mechanical responses of cells under either physiological or pathological conditions. A highly interdisciplinary approach interconnecting the computational methods of solid mechanics (finite element method in particular) with medical research is an inseparable part of the problem solution. A crucial step in proposing a computational model for approximation of a living cell behavior under loading conditions is to establish mechanically significant components to be incorporated into the calculation and to identify their material parameters. A presented computational model incorporates continuum entities such as the nucleus, membrane, and cytoplasm interconnected with a discrete mitochondrial network. This results in a novel hybrid model which is validated through comparison with experimental data and serves as a means to estimate the mitochondrial impact on overall cell stiffness.
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